VANIDERM L-Glutathione w/ Vitamin C
- Vendor: USA
- Type: Glutathione
VANIDERM
L-Glutathione with Vitamin C & Alpha Lipoic Acid
(Anti-oxidant, Anti-aging and for Fairer Skin)
COMMON NAME: GSH
CLINICAL NAME: Glutathione
SYNONYM: Reduced L- glutathione
CHEMICAL NAME: Gamma-L-glutamyl – L – cysteninylglycine or
L-7-glutanyl – cysteinylglycine
DEFINITION: L-Glutathione is biologically active sulfur amino acid tripeptide
compound consisting of:
· L-Cysteine
· L-Glutamic acid
· Glycine
FOUND WHERE?
present in virtually in all mammalian tissue mostly in liver where it detoxifies many harmful compounds to be excreted through the bile red and white blood cells lungs
- intestinal tract
PRIMARY BIOLOGICAL FUNCTIONS:
-to act as a non-enzymatic reducing agent to help keep cysteine thiol side chains in a reduce state on the surface of proteins
involved in the synthesis & repair of DNA transferase
-helps to recycle Vit. C and Vit. E
-blocks free radical damage
-enhances the anti-oxidant activity of Vit. C
-facilitates the transport of amino acids
-plays a critical role in the detoxification of harmful compounds
-is the base material for several other key antioxidant enzyme systems such as,glutathione-peroxidase, glutathione-reductase
-nd glutathione
Body (AID) A – ntioxidant I – mmune booster D – etoxifier
THEREFORE, declines in glutathione concentrations in intracellular fluids correlate directly with
indicators of aging.
DIETARY SOURCES:
Glutathione is derived from L-cysteine, L-glutamic acid and Glycine and is not consumed directly as a food constituent.
DEFICIENCY OF GLUTATHIONE CAUSES:
coordination problems
generalized cell damage
mental disorders
various nervous system disorders
tremors and twitching
red cells are prone to burst
whit blood cells decline in function
nerve tissue degenerates
DEFICIENCY OF INTRACELLULAR GLUTATHIONE has been associated with a variety of
conditions including
AIDS (acquired immune deficiency syndrome)
Alcohol induced liver diseases
Some forms of cancer
PROVEN THERAPEUTIC USES:
antioxidant action
cancer
cataracts
liver diseases
muscular degeneration
MECHANISM OF ACTION:
support of antioxidant process
modify the normal pigmentation pathway from eumelanin to pheomelanin
MAINTENANCE DOSE:
As Antioxidant and as Antiaging dose: 10mg per kilogram bodyweight per day
As Skin whitening: 20-40mg per kilo bodyweight per day in 2-3 divided doses.
Note: Best taken with preferably 30 minutes before meals. Should be taken together with
Vitamin C at least equal or twice the dose of the glutathione taken.
SIDE-EFFECTS:
Generally considered to be free of side-effects. No untoward side-effects nor interactions with
oral administration reported even in prolonged use.
It is SAFE. Classified as Food Supplement not a herbal. Made from genetically synthesize
molecules.
The only reported side- effect is SKIN WHITENING when taken in increased doses.
TOXICITY:
No toxicities have been reported or suspected as being associated with glutathione.
CONTRAINDICATIONS:
None known, except for use during some forms of chemotherapy and radiation where
antioxidants are contraindicated due to their inhibition of the free radical formation which is an
integral part of the therapeutic mechanism.
INTERACTIONS:
Nutrients affected by GLUTATHIONE – CISPLATIN and HALOPERIDOL
WHO NEEDS GLUTATHIONE:
40 years old and above smokers alcoholic drinkers with low immune system with liver problems with thyroid problems has cataracts with pimples obese with low sperm counts with cancer those who wants to possess fairer and whiter skin
LOW GLUTATHIONE LEVELS ARE FOUND IN:
Aging population Immunocompromised individuals With atherosclerosis Male infertility Pregnancy complications Hyperthyrodism Liver problems Cataracts Cancer Alzheimers, Parkinsons, M.S.
- Results of oxidative stress due to diseases, drugs pollution, radiation and smoking
IS IT SAFE IN THE LIVER?
“ The higher GSH content, the greater the liver’s capacity to detoxify harmful chemicals.”
“ When exposed to chemicals which damages the liver, concentration of GSH decreases.”
“ Reduction in GSH makes liver susceptible to damage.”
- Dr. Murray’s 7/2003
“ A small study in 8 patients of LIVER CANCER using oral GSH showed modest benefits when
given daily amounts of 500mg GSH.”
- Dalhoff, Ranek, et. Al., 1992
IS IT SAFE TO THOSE PERSONS WITH THYROID PROBLEMS?
YES.
“…both hypothyroidism and hyperthyroidism are associated with enhanced oxidative stress
involving antioxidants.”
- Reschu, Helsel, et. Al.
November, 2002
“…has a direct relationship with free radical formation and inverse relationship with levels of
erythrocute glutathione and glutathione peroxidase in human subjects.”
Turkish Journal of Endocrinology & Metabolism, Feb.,2001
Is it Safe for Pregnant Women?
Glutathione is generally safe since it is classified as processed food. There have been no
specific data established yet. But there are reports that clinicians use glutathione for better
fetus development because it is an anti-oxidant.
“Glutathione status plays an important role in the development of fetus because it controls cell
differentation, proliferation and cell death.
Placenta has a significant amount of G-S transferase which is capable of detoxification.
Supplementation can decrease the incidence of birth defects and protect the fetus from
damage.”
The Glutathione Report, Priya Shah, April 2004
GLUTATHIONE AND HEART/ NEUROLOGIC DISEASES/ DIABETIC MELLITUS
“CATALASE AND GSH Peroxidase were shown to potently decrease neurotoxity”
Journal of Neurochemistry, Vol. 87, Nov. 6, 2003, 1527-34
“Low levels of Glutathione Peroxidase activity in erythrocytes is associated with an increased
risk of Cardiovascular events in patients with coronary diseases.”
New England Journal of Medicine, 2003
DM & HYPERTENSIVE PATIENTS
- associated with INCREASED FREE RADICAL DEPENDENT OXIDATIVE TISSUE DAMAGE
Barbagallo, et al., 1999
WHAT IS THE DOSAGE?
Dosage computation as ANTIOXIDANT/ ANTI-AGING:
10 mg/kg/day
Ex. 50kg male
50kg body weight x 10mg = 500 mg/day
Dosage computation for SKIN WHITENING (double increased dose)
20-40 mg/kg/day
Ex. 50 kg female
50kg body wt x 30mg (median of 20 & 40) = 1500mg/ day in 3 divided doses
Duration of Intake for skin whitening:
Medium brown skin: 1-3 months
Dark brown skin: 3-6 months
Very brown skin: 6-12 months
Black skin: 2 years
Upon reaching desired skin color, maintenance dose of once a day.
Note: Grapeseed Extrtact 1,000mg should be taken together with Vaniderm to enhance and speedup whitenings processes.
Grapeseed extracts is 20x more powerful than Vit C and 50x more potent that Vit E.